Best Annexin A4 antibody

The annexins are a family of Ca2+ and phospholipid-binding proteins that regulate membrane trafficking and organization. They form homotrimers in the cytoplasm and can bind to damaged plasma membranes to restrict the movement of phospholipids and proteins. The annexins are also known to have a role in cell growth and apoptosis and to act as an anti-inflammatory molecule. ANXA4 is a member of the annexin family and, like other members of this protein family, is thought to bind to damaged plasma membranes where it can counteract the formation of holes in the membrane by binding to lipid bilayer components. ANXA4 is able to self-assemble around the edges of damage in plasma membranes into 2D ordered arrays that appear to restrict wound expansion through curvature forces. This link https://www.bosterbio.com/anti-annexin-iv-picoband-trade-antibody-a04840-boster.html

Anti-APC2 Antibody: Key Features and Benefits

This property has been credited with the ability of ANXA4 to facilitate the permeabilization of apoptotic cells in vitro. In addition, ANXA4 has been shown to be upregulated in a variety of cancers and is associated with chemoresistance in various tumor types including colorectal, gastric, esophageal squamous carcinoma (ESCC), endometrial carcinoma, lung cancer, pancreatic cancer, hepatocellular carcinoma, and breast cancer. In some cases, ANXA4 upregulation has been implicated in the resistance to paclitaxel and platinum in human cancers.